American researchers have conducted a small clinical trial to test a contraceptive pill intended for men. During a presentation at a congress, they announced that it had been well tolerated and that it reduced the levels of two hormones involved in the production of sperm
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This new pill is being tested by a team of researchers at the University of Washington School of Medicine and the Los Angeles Biomed Research Institute (LA BioMed), who have recruited 40 healthy young men for the first phase of testing. clinics. Ten participants were randomly given a placebo pill, while the rest of the men tested the new treatment, called 11-beta-methyl-19-nortestosterone dodecylcarbonate, Huge Review of Male Secret Pills.
Two strengths of pills were tested, 14 men received doses of 200 mg, and 16 received doses of 400 mg. All trial participants were to take their tablet (the pill or the placebo) once daily for 28 days.
Their findings, which were presented Sunday, March 24 at the annual meeting of the American Endocrine Society in New Orleans, showed that daily intake for a month significantly lowered the level of two hormones necessary for the production of sperm, compared to placebo.
No serious side effects
The effects of the drug were also reversible upon discontinuation of treatment, and participants did not report serious side effects. Mild side effects include fatigue, acne, headache, somewhat lowered libido, and mild erectile dysfunction, but sexual activity did not decrease. In addition, no participant stopped their treatment because of the side effects, and they were all diagnosed in good health after the test.
“Our results show that this pill, which combines two hormonal activities in one, will lower sperm production while preserving libido,” said researcher Christina Wang. In contrast, since the drug would need more than 28 days to produce effects on sperm production, the team of researchers notes that this trial was too short to observe optimal sperm suppression. The next step will be to conduct longer studies, and if this pill is found to be effective, larger studies will need to be done before testing it on sexually active couples.
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A hormonal, safe and reversible contraceptive should be available in about ten years
"A hormonal, safe and reversible contraceptive should be available in about ten years,"
predicted Dr. Wang, adding that a previous survey had shown that many men were open to the idea of a male contraceptive pill, so much. that its effects were reversible.
A new molecule, named JQ1, could be the future of male contraception. This compound used in the treatment against cancer made male mice infertile with no noticeable side effects ... other than a decrease in testicular volume. Will the male pill be prescribed in a few years?
Men and women are decidedly not quite equal. Because if the female contraceptive pill has existed since 1956, the male counterpart is still only an idea in the minds of scientists. Not enough to tax them as sexists, they are just limited by physiological considerations Huge Male Secret
Pills.
However, there is no shortage of attempts. A treatment with several hormones passes the test of fire by being tested by volunteers in a clinical trial. Even if it turned out to be effective, its large-scale use seems unlikely. Other molecules have been tested, but the side effects on health and fertility they engendered forced the laboratories not to insist further.
And now a new solution is on the horizon. Its name: JQ1. This compound, first used in the fight against cancer, has just demonstrated in the journal Cell all the interest it represents in the development of effective male contraception, by blocking spermatogenesis, the process of making spermatozoa. .
Men say they're ready to take the pill
The scientific community agrees that this discovery, coming from researchers at Baylor College of Medicine (Houston) and the Dana-Farber Cancer Institute (Boston), is significant. It is the first effective contraceptive that does not affect sex hormone levels. Although in the experiment, JQ1 was administered through the blood, the authors claim that an oral version, supplied in a pill, is quite conceivable.
In the meantime, the molecule is not yet ready to be tested in humans. Before that, these same scientists hope to find an even more specific derivative of JQ1 for better efficacy. A drug that will most likely remove the only side effect noticed, because if 70% of men in a recent study recognized that they were ready to take the pill if it were to be marketed, will they accept to see their virility undermined? ?
